@s2art uBlock Origin (there is one just called uBlock avoid that one) is by far the most effective and open source. AdGuard for Safari is a good one as well. Avoid Adblock plus as they have deals with advertisers to let some in.
This is a Mastodon instance primarily for Australasian Galleries, Libraries, Archives, Museums and Records people, and anyone else who wants to hang out with them. We use the Hometown fork which enables local-only posts.